Genetic influence of growth hormone receptor (GHR) polymorphisms on rabbit body weight: A meta-analysis

Growth and metabolism regulation in rabbits are influenced by the growth hormone receptor (GHR). However, despite its promising potential as candidate for marker assisted section, the association between GHR gene polymorphisms and body weight under different genetic models remains inconclusive. This study deployed systematic review and meta-analysis to assess this relationship. The protocol was retrospectively registered on the Open Science Framework. Following the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines, 17 data points from six studies were analyzed. Hardy-Weinberg Equilibrium (HWE) was tested, and four genetic models (co-dominant, dominant, recessive, and over-dominant) were fitted using OpenMeta? Analyst Software. Standardized mean differences (SMDs) were estimated using Cohen?s d method, with heterogeneity assessed via Q statistic, Tau-squared (??), H-squared (H?), and I-squared (I?). Egger?s regression test was used to evaluate publication bias and sensitivity analysis was conducted to determine single-study effects. There was significant association (p 0.05) under all other genetic models. Further, the results indicated that GG genotype had higher body weight than CG genotype. However, there was no difference (p>0.05) between CC and CG and CC and GG genotypes. This suggests that GHR gene polymorphisms have a limited influence on body weight and their impact may depend on specific genetic models.