Research identifies reference intervals for serum creatinine in various age and sex groups, suggesting integration into clinical practice can enhance care.
The use of indirect methods to establish RIs may capture population-specific differences that are not fully reflected by manufacturer-provided intervals. However, their results depend on rigorous preprocessing. Our results highlight that, while overall agreement exists among the TML and refineR approaches, careful consideration is needed for older patient groups where variability is higher. Ultimately, integrating locally derived RIs into clinical practice may improve patient care.
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Meyer et al. (2026) studied this question.
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