Co-amorphous system of icaritin-sodium taurodeoxycholate with improved solubility, antitumor efficacy and oral bioavailability

Tao Zhou; Haoxue Zhang; Xianghan Zhang; Lu Wang; Tingchi Wen; Jun He; Yixin Qian

doi:10.1039/d6ce00030d

January 1, 2026CrystEngComm

Co-amorphous system of icaritin-sodium taurodeoxycholate with improved solubility, antitumor efficacy and oral bioavailability

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Key Points

To evaluate the solubility, antitumor efficacy, and oral bioavailability of a co-amorphous system of icaritin and sodium taurodeoxycholate.
Developed a co-amorphous system using icaritin and sodium taurodeoxycholate.
Measured solubility and bioavailability in vitro and in vivo.
Assessed antitumor efficacy against hepatocellular carcinoma models.
The co-amorphous system significantly enhanced solubility compared to icaritin alone.
Increased oral bioavailability was observed in animal models.
Superior antitumor efficacy was reported in treated cancer models.

Implication

This research demonstrates the enhanced antitumor efficacy and bioavailability of icaritin in a co-amorphous system with sodium taurodeoxycholate, suggesting improved treatment options for liver...

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Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/69a91e57d6127c7a504c248b https://doi.org/10.1039/d6ce00030d

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Co-amorphous system of icaritin-sodium taurodeoxycholate with improved solubility, antitumor efficacy and oral bioavailability

Key Points

Implication

Abstract

Discussion

Cite This Study

Co-amorphous system of icaritin-sodium taurodeoxycholate with improved solubility, antitumor efficacy and oral bioavailability

Key Points

Implication

Abstract

Discussion

Cite This Study

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