What does this research mean for the field?

Kefir and its by-products reduce inflammation and oxidative stress, improve intestinal barrier integrity, and modulate gut microbiota in animal models of inflammatory bowel disease. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

The review synthesizes evidence on the effects of kefir on inflammation, oxidative stress, and gut health in animal models of inflammatory bowel disease.

March 5, 2026Probiotics and Antimicrobial ProteinsOpen Access

Kefir and Its By-Products Supplementation Reduces Inflammation and Oxidative Stress, Improves Intestinal Barrier Integrity, and Modulates the Gut Microbiota in Animal Models of Inflammatory Bowel Disease: A Systematic Review

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Authors

MNMaria Alice Spadarotto NevesUniversidade Federal de Viçosa RPRayanne Santos de PauloUniversidade Federal de Viçosa JBJosefina BressanUniversidade Federal de Viçosa

Discussion

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Implication

Systematic review reveals kefir reduces inflammation in animal models of IBD, suggesting its therapeutic potential.

Key Points

The review synthesizes evidence on the effects of kefir on inflammation, oxidative stress, and gut health in animal models of inflammatory bowel disease.
Conducted a systematic review following PRISMA guidelines.
Utilized databases including PubMed/MEDLINE, Web of Science, Embase, and Scopus.
Assessed study quality using SYRCLE’s Risk of Bias tool.
Included sixteen experimental studies involving 585 rodents with chemically induced colitis.
Evaluated the effects of various kefir formulations and isolated microorganisms.
Most studies reported significant reductions in inflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Antioxidant effects were supported by reduced levels of MDA and H₂O₂, alongside observed changes in antioxidant enzyme activity.
Kefir improved gut microbiota composition and upregulated tight junction protein expression.
Clinical parameters of IBD models showed improvements, including reduced disease activity index and rectal bleeding.
Methodological limitations and heterogeneity among studies were noted, indicating a need for further research.

Cite This Study

Neves et al. (2026) studied this question.

synapsesocial.com/papers/69a91e57d6127c7a504c24e8 https://doi.org/10.1007/s12602-026-10948-5

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Kefir and Its By-Products Supplementation Reduces Inflammation and Oxidative Stress, Improves Intestinal Barrier Integrity, and Modulates the Gut Microbiota in Animal Models of Inflammatory Bowel Disease: A Systematic Review

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Key Points

Cite This Study

Kefir and Its By-Products Supplementation Reduces Inflammation and Oxidative Stress, Improves Intestinal Barrier Integrity, and Modulates the Gut Microbiota in Animal Models of Inflammatory Bowel Disease: A Systematic Review

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Key Points

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