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March 5, 2026Journal of Virology2 citationsOpen Access

Animal organoids as transformative platforms for viral infections and zoonotic cross-species viral research

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IGInés García-RodríguezJHJulian A. HiscoxCACarlos Alonso

Key Points

  • To explore the role of animal-derived organoids in studying viral infections and zoonotic diseases.
  • Review of organoid technology developments
  • Comparison of human and animal organoid applications
  • Analysis of species-specific responses to viral infections
  • Animal organoids replicate native tissue architecture
  • Facilitate studies on viral infection responses
  • Enhance preparedness strategies for zoonotic diseases

Abstract

Organoids have revolutionized human biomedical research since their development in 2010. However, as nearly 75% of human infectious diseases originate in animals, animal-derived organoids are essential to complement human models, yet their development in veterinary contexts remains scarce. Organoids replicate native tissue architecture, enabling species-specific and comparative studies of viral infection and host response. Thus, animal organoids represent a powerful field in organoid technology, advancing cross-species virology research and strengthening strategies for zoonotic disease preparedness.

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Cite This Study

García-Rodríguez et al. (2026) studied this question.

synapsesocial.com/papers/69a91e65d6127c7a504c261dhttps://doi.org/10.1128/jvi.02197-25
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