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This research aims to develop a rapid test for detecting antibodies against Rift Valley fever virus (RVFV) using a novel double-antigen approach.

March 5, 2026VirusesOpen Access

A Species-Independent Lateral Flow Test to Detect Rift Valley Fever Virus Antibodies Using a Double Antigen Approach

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Lateral flow test detects RVFV antibodies in multiple species, suggesting faster disease monitoring and control.

This research aims to develop a rapid test for detecting antibodies against Rift Valley fever virus (RVFV) using a novel double-antigen approach.
Developed a capillary flow immunodiagnostic test to detect RVFV-specific antibodies.
Utilized immune sera from sheep, calves, goats, and humans for validation.
Benchmarking against a new double-antigen ELISA and a commercial competition ELISA.
The lateral flow test demonstrated high sensitivity and specificity.
Similar high performance was observed for the double-antigen ELISA.
The advancement brings practical implementation of RVFV-specific pen-side testing closer.

Schreur et al. (2026) studied this question.

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