What question did this study set out to answer?

The study aims to evaluate serum magnesium levels and their independent predictive value for insulin resistance in early chronic kidney disease.

March 5, 2026Open Access

Serum Magnesium as an Independent Predictor of Insulin Resistance in Early Chronic Kidney Disease

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Authors

SKSuresh KumarCentral Institute for Research on Cattle BDBELLA DAYOJinnah Postgraduate Medical Center BHBabeeta HindujaJinnah Postgraduate Medical Center

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Implication

Analytical cross-sectional study examines serum magnesium's role in predicting insulin resistance in early CKD, suggesting its potential as a metabolic marker.

Key Points

The study aims to evaluate serum magnesium levels and their independent predictive value for insulin resistance in early chronic kidney disease.
Conducted as an analytical cross-sectional study at Jinnah Postgraduate Medical Centre in Karachi.
Involved 180 adults with CKD stages 1-3, enrolled through consecutive sampling.
Analyzed fasting blood samples for serum magnesium, glucose, insulin, and other biomarkers.
Assessed insulin resistance using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR).
Performed statistical analyses including one-way ANOVA and multivariate linear regression.
Serum magnesium levels significantly decline with advancing CKD stage (p<0.001).
HOMA-IR increases progressively across CKD stages (p<0.001).
A significant inverse correlation exists between serum magnesium and HOMA-IR (r = −0.52, p<0.001).
Serum magnesium is an independent predictor of insulin resistance after adjusting for confounding factors (β = −0.38, p<0.001).

Cite This Study

Kumar et al. (2026) studied this question.

synapsesocial.com/papers/69a91e65d6127c7a504c26d8 https://doi.org/10.5281/zenodo.18846884

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Implication

Analytical cross-sectional study examines serum magnesium's role in predicting insulin resistance in early CKD, suggesting its potential as a metabolic marker.

Serum Magnesium as an Independent Predictor of Insulin Resistance in Early Chronic Kidney Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Serum Magnesium as an Independent Predictor of Insulin Resistance in Early Chronic Kidney Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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