What question did this study set out to answer?

The aim is to explore how vitamin D influences colorectal cancer cell development through gut microbiota and immune responses.

March 5, 2026

Vitamin D inhibits the development of colorectal cancer cells by regulating the gut microbiota and immune microenvironment using JAKSTAT signaling pathway.

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The aim is to explore how vitamin D influences colorectal cancer cell development through gut microbiota and immune responses.
Examined the effect of vitamin D on the JAK-STAT pathway activation.
Analyzed gut microbiota composition and butyrate metabolism.
Assessed macrophage polarization in response to vitamin D treatment.
Vitamin D reduced the activation of the JAK-STAT pathway.
Restoration of butyrate metabolism was observed.
Macrophage polarization was rebalanced, indicating improved immune response.

Implication

Demonstrates how vitamin D regulates gut microbiota and immune functions to inhibit colorectal cancer development.

Abstract

Vitamin D inhibits excessive activation of the JAK-STAT pathway through VDR activation, ameliorates gut microbiota dysbiosis, restores butyrate metabolism, and rebalances macrophage polarization.

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Cite This Study

Bai et al. (2026) studied this question.

synapsesocial.com/papers/69a91f0ad6127c7a504c28af https://doi.org/10.1080/08923973.2026.2630162

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Implication

Demonstrates how vitamin D regulates gut microbiota and immune functions to inhibit colorectal cancer development.

Abstract

Vitamin D inhibits excessive activation of the JAK-STAT pathway through VDR activation, ameliorates gut microbiota dysbiosis, restores butyrate metabolism, and rebalances macrophage polarization.

Vitamin D inhibits the development of colorectal cancer cells by regulating the gut microbiota and immune microenvironment using JAKSTAT signaling pathway.

Key Points

Implication

Abstract

Discussion

Cite This Study

Vitamin D inhibits the development of colorectal cancer cells by regulating the gut microbiota and immune microenvironment using JAKSTAT signaling pathway.

Key Points

Implication

Abstract

Discussion

Cite This Study

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