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March 6, 2026Frontiers in OncologyOpen Access

Case Report: transcavernous sinus resection of parotid carcinoma with perineural invasion to Meckel’s cave and cavernous sinus

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Authors

LCLi CaiErasmus MCRDRuben DammersErasmus MCERElise G. RushingUniversity of Arkansas for Medical Sciences

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Implication

Case report demonstrates curative resection of parotid ACC invading cavernous sinus, highlighting safe microsurgical techniques.

Key Points

  • To detail a specialized approach for resecting parotid adenoid cystic carcinoma (ACC) with significant perineural invasion into critical areas.
  • 54-year-old male presented with neurological symptoms due to tumor invasion.
  • Conducted MRI and PET-CT to assess tumor extent and rule out metastasis.
  • Used a modified Dolenc extradural approach for skull base surgery, avoiding extensive bone removal.
  • Performed fascicular-level nerve reconstruction and multilayer skull base closure.
  • Achieved gross total tumor resection while preserving ICA and cranial nerve integrity.
  • No new neurological deficits were observed post-surgery; existing issues remained stable.
  • Pathology confirmed extensive perineural invasion, necessitating further treatment with radiation.

Cite This Study

Cai et al. (2026) studied this question.

synapsesocial.com/papers/69aa6ee2531e4c4a9ff590a7https://doi.org/10.3389/fonc.2026.1741177
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