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March 6, 2026In vitro modelsOpen Access

Generation of mixed ovarian cancer and fibroblast spheroids by bioprinting

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Authors

AAArjan AtwalKeele UniversityARAlan RichardsonKeele University

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Implication

This bioprinting study models ovarian cancer and fibroblasts to examine drug responses, suggesting innovative testing methods.

Key Points

  • The aim is to create a realistic 3D model of ovarian cancer and fibroblasts to better predict drug responses.
  • Developed a droplet-bioprinted ovarian cancer model with OVCAR-4 cells and primary cancer-associated fibroblasts.
  • Embedded cells in a collagen-based hydrogel for controlled architecture.
  • Evaluated cancer and fibroblast cell density and chemotherapeutic response systematically.
  • Spheroids displayed good reproducibility in luminescence and architecture across different conditions.
  • Higher cancer cell density increased luminescence non-linearly but could be normalized based on initial cell number.
  • CAFs boosted cancer cell growth but did not confer resistance to carboplatin, indicating separate mechanisms for growth support and chemoresistance.

Cite This Study

Atwal et al. (2026) studied this question.

synapsesocial.com/papers/69aa6f0d531e4c4a9ff59379https://doi.org/10.1007/s44164-026-00107-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CAF promotes chemoresistance through NRP2 in gastric cancer2021 · 59 citations
  2. 2STING inhibitors sensitize platinum chemotherapy in ovarian cancer by inhibiting the CGAS-STING pathway in cancer-associated fibroblasts (CAFs)2024 · 48 citations
  3. 3Potential mechanisms of cancer-associated fibroblasts in therapeutic resistance2023 · 66 citations
  4. 4A Coculture Based, 3D Bioprinted Ovarian Tumor Model Combining Cancer Cells and Cancer Associated Fibroblasts2022 · 37 citations
  5. 5Cisplatin-induced CCL5 secretion from CAFs promotes cisplatin-resistance in ovarian cancer via regulation of the STAT3 and PI3K/Akt signaling pathways2016 · 113 citations