Pre-treatment NLR and Changes in NLR Are Associated With Survival Following the Initiation of Immune Checkpoint Inhibitor Therapy in Patients With Non-small Cell Lung Cancer.

Minehiko Inomata; Yuki Matsushiro; Yuki Tanabe; Moe Hashizume; Kenji Azechi; Nozomu Murayama; Naoki Takata; Zenta Seto; Kotaro Tokui; Seisuke Okazawa; Shingo Imanishi; RYUJI HAYASHI; Mosaburo Kainuma

doi:10.21873/cdp.10536

March 4, 2026Open Access

Pre-treatment NLR and Changes in NLR Are Associated With Survival Following the Initiation of Immune Checkpoint Inhibitor Therapy in Patients With Non-small Cell Lung Cancer.

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Key Points

To investigate the relationship between pre-treatment NLR and changes in NLR with survival outcomes after starting immune checkpoint inhibitor therapy.
Measured pre-treatment NLR levels in patients with non-small cell lung cancer prior to therapy.
Monitored changes in NLR following the initiation of immune checkpoint inhibitors.
Assessed progression-free survival in relation to NLR changes and other clinical factors.
Higher pre-treatment NLR was linked to improved progression-free survival after therapy initiation.
A significant change in NLR during treatment correlated with better survival outcomes.
Cytotoxic agent use and the presence of liver metastases were potentially associated with NLR changes.

Implication

Observational study associates NLR changes with progression-free survival in lung cancer, implying potential prognostic value.

Abstract

Pre-treatment NLR and a change in NLR were associated with progression-free survival after the initiation of ICI therapy. Furthermore, concomitant use of cytotoxic agents and liver metastases may be associated with a change in NLR.

Discussion

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Cite This Study

Inomata et al. (2026) studied this question.

synapsesocial.com/papers/69aa6f0d531e4c4a9ff59390 https://doi.org/10.21873/cdp.10536

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Pre-treatment NLR and Changes in NLR Are Associated With Survival Following the Initiation of Immune Checkpoint Inhibitor Therapy in Patients With Non-small Cell Lung Cancer.

Key Points

Implication

Abstract

Discussion

Cite This Study

Pre-treatment NLR and Changes in NLR Are Associated With Survival Following the Initiation of Immune Checkpoint Inhibitor Therapy in Patients With Non-small Cell Lung Cancer.

Key Points

Implication

Abstract

Discussion

Cite This Study

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