Novel complexes enhance phosphodiesterase inhibition in tetrahedral iron compounds, suggesting potential therapeutic uses.
Nitrosyl complexes of tetrahedral iron—nitric oxide (NO) donors—with 5-substituted 1,3,4-oxadiazole-2-thiols were obtained for the first time. According to elemental analysis data, spectral methods, and quantum chemical calculations, there are paramagnetic tetrairon nitrosyl complexes of the μ-NCS structural type. The NO-donor properties and the effect of the obtained compounds on phosphodiesterase (PDE) activity were studied. It was shown that the synthesized complexes exhibit effective PDE inhibitory activity.
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Syreyshchikova et al. (2026) studied this question.
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