Key result
Dinitrosyl iron complexes with thiol-containing ligands act as an endogenous working form of the nitric oxide system and suppress SARS-CoV-2 infection in Syrian hamsters.
DNICs serve as a functional working form of the NO system with potential therapeutic applications, including the suppression of SARS-CoV-2.
DNICs may support NO-based antiviral strategies in models; leaves open human translation and requires prospective trials.
Experimental data were summarized to assume that dinitrosyl iron complexes (DNICs) with thiol-containing ligands are an endogenous "working form" of the nitric oxide (NO) system in living organisms. DNICs can function as donors of both neutral NO molecules, which are responsible for positive regulatory effects of the NO system on various physiological and biochemical processes in humans and animals, and nitrosonium cations (NO^(+)), which are responsible mostly for negative cytotoxic activity of the system. Special attention is paid to the finding that DNICs, especially in combination with dithiocarbamate derivatives, suppress SARS-CoV-2 infection in Syrian hamsters.
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А. Ф. Ванин (2023) conducted a review in SARS-CoV-2 infection. Dinitrosyl iron complexes (DNICs) with thiol-containing ligands was evaluated. Dinitrosyl iron complexes with thiol-containing ligands act as an endogenous working form of the nitric oxide system and suppress SARS-CoV-2 infection in Syrian hamsters.
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