What question did this study set out to answer?

The main goal is to create an accurate framework for predicting overall survival in patients with inoperable locally advanced NSCLC treated with immunotherapy.

March 6, 2026Frontiers in ImmunologyOpen Access

Cross-dataset adaptation of voxel-level deep radiomics for predicting survival in inoperable locally advanced NSCLC treated with immunotherapy

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Authors

JWJin WangZhejiang Cancer Hospital ZJZhaoyu JiangColorado School of Public Health WJWenhao JiZhejiang Chinese Medical University

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Implication

Analysis demonstrates improved survival prediction in advanced lung cancer patients treated with immunotherapy, indicating enhanced prognostic strategies.

Key Points

The main goal is to create an accurate framework for predicting overall survival in patients with inoperable locally advanced NSCLC treated with immunotherapy.
Analyzed data from 526 patients, using a non-immunotherapy dataset for pre-training.
Developed a Vision-Mamba deep learning model to extract tumor features from CT images.
Employed a cross-dataset transfer learning strategy to adapt models to the immunotherapy dataset.
Evaluated performance using concordance index, AUC, Kaplan-Meier analysis, and Grad-CAM.
Achieved a C-index of 0.73 in the independent immunotherapy testing dataset.
Predicted 1-year and 2-year OS AUCs were 0.73 and 0.70, respectively.
Calibration curves indicated strong agreement between predicted and actual survival probabilities.
High-risk group showed significantly poorer OS compared to low-risk group (P<0.001).

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69aa7008531e4c4a9ff596ce https://doi.org/10.3389/fimmu.2026.1787518

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Implication

Analysis demonstrates improved survival prediction in advanced lung cancer patients treated with immunotherapy, indicating enhanced prognostic strategies.

Cross-dataset adaptation of voxel-level deep radiomics for predicting survival in inoperable locally advanced NSCLC treated with immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Cross-dataset adaptation of voxel-level deep radiomics for predicting survival in inoperable locally advanced NSCLC treated with immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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