Efficacy of NAs in combination with Peg-IFN for functional cure in patients with CHB: a meta-analysis of RCTs.

Key Points

• The analysis investigates the effectiveness of combining NAs with Peg-IFN for achieving a functional cure in patients with chronic hepatitis B (CHB).
• Conducted a meta-analysis of randomized controlled trials (RCTs)
• Compared functional cure rates between combination therapy and monotherapy
• Evaluated incidence of ALT flares in both treatment groups.
• Combination therapy significantly improves functional cure rates compared to NAs alone
• No added benefit of combination therapy over Peg-IFN monotherapy in achieving functional cure
• Peg-IFN monotherapy had a higher incidence of ALT flares compared to combination therapy.