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February 1, 2026Nigerian Journal of Clinical PracticeOpen Access

LINC00963 Targets miR-495-3p to Regulate Pancreatic Cancer Cell Proliferation, Apoptosis, and Carboplatin Sensitivity

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Key Points

To investigate the role of LINC00963 in pancreatic cancer cell growth, apoptosis, and response to carboplatin treatment.
Examined the downregulation of LINC00963 in pancreatic cancer cells
Measured changes in miR-495-3p levels
Assessed cell proliferation and apoptosis rates
Evaluated sensitivity to carboplatin
Downregulation of LINC00963 correlated with decreased cell proliferation
Increased levels of miR-495-3p were observed upon LINC00963 downregulation
Enhanced sensitivity to carboplatin treatment was noted in pancreatic cancer cells after LINC00963 knockdown

Implication

LINC00963 downregulates to enhance carboplatin sensitivity in pancreatic cancer cells, indicating a potential therapeutic target.

Abstract

LINC00963 downregulation could block PC cell progression and elevate their sensitivity to carboplatin through accelerating miR-495-3p level.

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Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/69aa7048531e4c4a9ff59eaf https://doi.org/10.4103/njcp.njcp_886_24

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