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March 6, 2026Operative Neurosurgery

Combined Surgical Resection and Responsive Neurostimulation for Drug-Resistant Epilepsy: A Case Series

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Authors

GRGabriel ReyesBaylor College of MedicineNGNisha GiridharanBaylor College of MedicineBSBen ShotyUniversity of Utah

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Implication

Retrospective analysis finds improved seizure control in patients with drug-resistant epilepsy using combined R+RNS.

Key Points

  • To assess the efficacy of a combined approach of subtotal surgical resection and responsive neurostimulation in improving seizure control in patients with drug-resistant epilepsy.
  • Retrospective study of patients with focal drug-resistant epilepsy who underwent combined R + RNS.
  • Inclusion of patients with at least 6 months of follow-up post-treatment.
  • Assessment of seizure frequency, severity, subjective improvements, and seizure-free periods.
  • Seven patients underwent R + RNS with a mean follow-up of 20.7 months.
  • Mean reduction in seizure frequency was 79.3%, with three patients (42.9%) achieving initial seizure freedom post-resection.
  • RNS activation restored sustained seizure freedom in all three patients who experienced recurrence.

Cite This Study

Reyes et al. (2026) studied this question.

synapsesocial.com/papers/69aa705a531e4c4a9ff5a07dhttps://doi.org/10.1227/ons.0000000000001962
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