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Parathyroid Hormone Contributes to Pulmonary Hypertension in Hypoxic Conditions | Synapse

March 6, 2026

Parathyroid Hormone Contributes to Pulmonary Hypertension in Hypoxic Conditions

Key Points

This research investigates how parathyroid hormone (PTH) and its receptor contribute to pulmonary hypertension under low oxygen conditions.
Clinical assessments of pulmonary hypertension in individuals with hypoxia
Experimental studies analyzing PTH/PTH1R signaling pathways
Evaluation of treatment approaches targeting PTH1R
PTH signaling is linked to the development of pulmonary hypertension
Increased PTH levels correlate with worsening hypoxic conditions
Targeting PTH1R may offer new therapeutic strategies.

Abstract

Our clinical and experimental data suggest a potential involvement of PTH/PTH1R signaling in the development and progression of PH, highlighting PTH1R as a possible therapeutic target for further investigation.

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Cite This Study

Joki et al. (Wed,) studied this question.

synapsesocial.com/papers/69aa705a531e4c4a9ff5a09d https://doi.org/https://doi.org/10.1161/circresaha.125.327401

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Parathyroid hormone accelerates decompensation following left ventricular hypertrophy2010 · 35 citations
2Parathyroid hormone and parathyroid hormone-related peptide, and their receptors2004 · 298 citations
3The Sexual Dimorphism Associated with Pulmonary Hypertension Corresponds to a Fibrotic Phenotype2015 · 56 citations
4Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues.1993 · 302 citations
5A Case-Comparison Study of Hypertension and Hyperparathyroidism*1982 · 66 citations