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March 6, 2026Neurology InternationalOpen Access

Neurotrophins Plasma Levels Kinetics in Ischemic Stroke Patients—Potential Relation to Outcomes

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Authors

RORadosław OpiłaKŁKarolina ŁuczkowskaEPEdyta Paczkowska

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Overview

Observational study finds BDNF levels relate to outcomes in ischemic stroke patients, suggesting implications for treatment.

Key Points

  • To investigate the relationship between plasma levels of neurotrophins and clinical outcomes in ischemic stroke patients.
  • Measured plasma levels of neurotrophins (BDNF, NGF, NT-3, NT-4) of 93 ischemic stroke patients.
  • Collected data at two time points: within 24 hours and on the seventh day after onset.
  • Analyzed clinical data including NIHSS scores and mortality rates in relation to neurotrophin levels.
  • BDNF levels were lower in patients with severe stroke and negatively correlated with NIHSS scores.
  • No significant associations were found for NGF and NT-3 with stroke outcomes.
  • Patients who died exhibited lower baseline levels of BDNF and NT-4, and higher levels of NT-3.

Cite This Study

Opiła et al. (2026) studied this question.

synapsesocial.com/papers/69aa7066531e4c4a9ff5a21bhttps://doi.org/10.3390/neurolint18030051
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