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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a1467 Biomarkers of Neuroplasticity in Predicting Outcomes of Hemorrhagic Stroke

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Authors

FMFayzullo MallaevGRGulnora RakhimbaevaGUGulchexra Usmanova

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Overview

Randomized trial evaluates GDNF levels as predictors of outcomes in patients with hemorrhagic stroke, suggesting therapeutic relevance.

Key Points

  • The aim is to assess the role of GDNF in predicting outcomes during the acute phase of hemorrhagic stroke.
  • Examined 83 patients with hemorrhagic stroke of various localizations in the acute phase
  • Measured serum GDNF levels and assessed neurological status using NIHSS, FOUR score, Barthel Index, and modified Rankin Scale
  • Compared GDNF levels in patients to a control group
  • Control group mean GDNF level was 28.1 pg/mL; hemorrhagic stroke patients had levels of 46.7 pg/mL within 3 hours (p<0.05)
  • By day 14, GDNF levels decreased to 35.3 pg/mL (p<0.05 compared to control)
  • Patients with favorable clinical course showed increased GDNF levels on day 14, while unfavorable cases had stable or decreasing levels.

Cite This Study

Mallaev et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f3abfa21ec5bbf079bahttps://doi.org/10.1093/esj/aakag023.1571
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract WP379: Biomarkers of neuroplasticity in predicting outcomes of hemorrhagic strokes2026
  2. 2ABSTRACT NUMBER: ESOC2026A1457 THE RELATIONSHIP BETWEEN LEVELS OF NEUROINFLAMMATORY BIOMARKERS AND NEUROPLASTICITY IN THE ACUTE PERIOD OF HEMORRHAGIC STROKES2026
  3. 3Neurotrophins Plasma Levels Kinetics in Ischemic Stroke Patients—Potential Relation to Outcomes2026
  4. 4ABSTRACT NUMBER: ESOC2026A2083 EARLY PLASMA NFL PREDICTS COGNITIVE OUTCOMES 5 YEARS AFTER STROKE2026
  5. 5Serum biomarker dynamics for predicting clinical outcomes and hemorrhagic transformation in acute ischemic stroke:A prospective cohort study2026