Perivascular Spaces Are Associated With CSF Aβ in Cerebral Amyloid Angiopathy But Not in Deep Perforator Arteriopathy

Key Points

• This study aims to explore the relationship between perivascular spaces and amyloid beta pathology in different subtypes of cerebral small vessel disease.
• Analyzed perivascular spaces in relation to cerebrospinal fluid amyloid beta levels
• Examined two conditions: cerebral amyloid angiopathy and deep perforator arteriopathy
• Utilized neuroimaging and histopathologic assessments
• Confirmed a significant association between perivascular spaces and amyloid beta in cerebral amyloid angiopathy
• No similar association was found in deep perforator arteriopathy
• The findings highlight the importance of considering cerebral small vessel disease subtype when interpreting perivascular spaces.