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This research aims to evaluate how different Wolbachia strains influence the ability of Aedes aegypti mosquitoes to transmit DENV-1.

March 6, 2026Parasites & VectorsOpen Access

Wolbachia wMel and wAlbB strains differentially impact the vector competence of Aedes aegypti with a Brazilian genetic background for DENV-1 virus

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Study investigates how Wolbachia strains affect DENV-1 transmission in Aedes aegypti, suggesting implications for dengue control.

This research aims to evaluate how different Wolbachia strains influence the ability of Aedes aegypti mosquitoes to transmit DENV-1.
Infection of 493 mosquitoes with w Mel and w AlbB strains
Oral challenge with low and high titers of DENV-1
Measurement of Wolbachia density using qPCR
Assessment of viral infection in mosquito bodies and saliva via RT-qPCR
Analysis of infection prevalence and viral loads at 7, 14, and 21 days post infection
Both w Mel and w AlbB strains decreased DENV-1 infection compared to wild type mosquitoes.
w Mel showed higher inhibition of DENV-1 despite lower bacterial density than w AlbB.
Viral loads remained constant in mosquito bodies over time for both strains.
Transmission rates in saliva were similar at early time points but lowered by 21 days for both strains.
Findings suggest a maximum capacity for Wolbachia to block DENV-1.

Martins et al. (2026) studied this question.

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