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This research aims to visualize blood cell dynamics and occlusion mechanisms in sickle cell disease using a novel imaging technique.

March 6, 2026Blood Advances0 citationsOpen Access

In Vivo Visualization of Sickle Cell Microvascular Occlusion and Hemorheological Indices

Sickle cell visualization in vivo in humans: microvascular occlusion formation and hemorheological indices

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Demonstrates blood flow dynamics in sickle cell disease, highlighting potential therapeutic evaluations.

This research aims to visualize blood cell dynamics and occlusion mechanisms in sickle cell disease using a novel imaging technique.
Used oblique back-illumination microscopy to observe blood flow in sublingual capillaries.
Captured videos of 91.0 ± 42.3 capillaries in ten sickle cell disease subjects and ten controls before and after transfusions.
Classified blood flow as fast, slow, or no flow, and counted adhered red blood cells.
SCD subjects had fewer fast-flowing vessels (48.7%) compared to controls (77.7%).
Increased number of no flow vessels in SCD subjects (16.1% vs. 2.4% in controls).
After transfusion, SCD microvasculature showed improved flow dynamics with more fast-flowing vessels (65.8%) and fewer no flow vessels (6.0%).

Morakis et al. (2026) studied this question.

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March 6, 2026Blood Advances0 citationsOpen Access

Sickle cell visualization in vivo in humans: microvascular occlusion formation and hemorheological indices

View Full Paper

Ask AI

Bookmark

Authors

Demonstrates blood flow dynamics in sickle cell disease, highlighting potential therapeutic evaluations.

This research aims to visualize blood cell dynamics and occlusion mechanisms in sickle cell disease using a novel imaging technique.
Used oblique back-illumination microscopy to observe blood flow in sublingual capillaries.
Captured videos of 91.0 ± 42.3 capillaries in ten sickle cell disease subjects and ten controls before and after transfusions.
Classified blood flow as fast, slow, or no flow, and counted adhered red blood cells.
SCD subjects had fewer fast-flowing vessels (48.7%) compared to controls (77.7%).
Increased number of no flow vessels in SCD subjects (16.1% vs. 2.4% in controls).
After transfusion, SCD microvasculature showed improved flow dynamics with more fast-flowing vessels (65.8%) and fewer no flow vessels (6.0%).

Morakis et al. (2026) studied this question.

View Full Paper

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