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The aim was to explore how L. curvatus IM01 affects allergic airway inflammation and the underlying mechanisms involved.

March 6, 2026NutrientsOpen Access

Latilactobacillus curvatus IM01 Alleviates Allergic Airway Inflammation Through Microbial and Metabolic Crosstalk Along the Gut–Lung Axis

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The aim was to explore how L. curvatus IM01 affects allergic airway inflammation and the underlying mechanisms involved.
Utilized an ovalbumin-induced murine model of allergic airway inflammation.
Administered L. curvatus IM01 orally to observe its effects on inflammation and immune responses.
Employed an integrated multi-omics approach including 16S rRNA sequencing and untargeted metabolomics.
L. curvatus IM01 significantly reduced airway inflammation and suppressed Th2 immune responses.
The administration led to decreased serum IgE levels and a shift in gut microbial composition.
Metabolomic analysis revealed restoration of immunoregulatory metabolites linked to reduced AAI symptoms.

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Demonstrates that Latilactobacillus curvatus IM01 reduces airway inflammation in a mouse model, suggesting therapeutic benefits for allergies.

He et al. (2026) studied this question.

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Demonstrates that Latilactobacillus curvatus IM01 reduces airway inflammation in a mouse model, suggesting therapeutic benefits for allergies.