Findings show regional nodal irradiation does not increase lymphedema or surgical morbidity in high-risk populations, suggesting potential benefits of intervention.
RNI in the setting of ILR was not associated with increased surgical morbidity, lymphedema rates, or adverse patient-reported outcomes. While ILR may mitigate the expected morbidity of RNI, prospective studies are needed to establish its definitive value in this high-risk population.
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Hassan et al. (2026) studied this question.
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