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March 6, 2026Endocrinology and MetabolismOpen Access

Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials

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SKSung Hye Kong

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Overview

This review evaluates vitamin D's role in fracture prevention, suggesting tailored approaches for optimal outcomes.

Key Points

  • The aim is to re-evaluate vitamin D's role in fracture prevention based on recent trial findings and propose a new framework.
  • Review of large-scale randomized controlled trials
  • Analysis of epidemiological studies
  • Exploration of the divergent threshold hypothesis
  • Recent trials did not replicate the fracture prevention benefits of vitamin D.
  • High-dose bolus administration may increase fall risk.
  • A serum level of 20 to 30 ng/mL may suffice for skeletal health, while 40 to 50 ng/mL is needed for metabolic benefits.

Cite This Study

Sung Hye Kong (2026) studied this question.

synapsesocial.com/papers/69aa70c8531e4c4a9ff5aea6https://doi.org/10.3803/enm.2029.2938
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials2026
  2. 2Effect of vitamin D on risk of falls and fractures – The contribution of recent mega-trials2024 · 13 citations
  3. 3The vitamin D story – a 2023 update on fractures and falls2024 · 1 citations
  4. 4From the Vitamin D Paradox to Precision Nutrition: Targeted Supplementation, Assay Pitfalls, and Clinical Decision-Making2026 · 2 citations
  5. 5Rethinking Vitamin D Deficiency: Controversies and Practical Guidance for Clinical Management2025 · 1 citations