What does this research mean for the field?

Weight-adjusted waist index (WWI) and plasma lipocalin-2 (LCN2) are independently associated with mild cognitive impairment (MCI) in patients with type 2 diabetes. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to assess the relationship between weight-adjusted waist index (WWI), lipocalin-2, and mild cognitive impairment (MCI) in patients with type 2 diabetes.

March 6, 2026European journal of medical researchOpen Access

Development and validation of a risk prediction model integrating WWI and lipocalin-2 for cognitive impairment in patients with type 2 diabetes

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Authors

KLKunyu LiuZhongda Hospital Southeast University TNTong NiuZhongda Hospital Southeast University JZJunru ZhouZhongda Hospital Southeast University

Discussion

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Implication

Cross-sectional evaluation reveals WWI and lipocalin-2 predict cognitive impairment in type 2 diabetes, suggesting improved risk assessment methods.

Key Points

This research aims to assess the relationship between weight-adjusted waist index (WWI), lipocalin-2, and mild cognitive impairment (MCI) in patients with type 2 diabetes.
Conducted a cross-sectional study with 410 patients having type 2 diabetes.
Collected anthropometric data, metabolic indices, LCN2 levels, and neuropsychological test scores.
Divided participants into training (70%) and validation (30%) cohorts for model development.
Used LASSO regression for predictor selection and multivariable logistic models for analysis.
Evaluated model performance based on discrimination and calibration across cohorts.
Participants with MCI had significantly higher WWI and LCN2 levels compared to those with normal cognition.
After adjusting for other factors, WWI and LCN2 remained significant predictors of MCI with notable odds ratios.
The multivariable model showed satisfactory discrimination with AUC values of 0.745 and 0.774 in training and validation cohorts, respectively.
The combined model outperformed individual predictors, indicating the potential for better cognitive risk stratification.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69aa710d531e4c4a9ff5b51c https://doi.org/10.1186/s40001-026-04164-8

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Implication

Cross-sectional evaluation reveals WWI and lipocalin-2 predict cognitive impairment in type 2 diabetes, suggesting improved risk assessment methods.

Development and validation of a risk prediction model integrating WWI and lipocalin-2 for cognitive impairment in patients with type 2 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Development and validation of a risk prediction model integrating WWI and lipocalin-2 for cognitive impairment in patients with type 2 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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