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March 3, 2026

Whiteout sign on dSIR MRI: A case series highlighting symptom-associated white matter changes not observed on standard T₂-FLAIR.

Joshua P. McGeown Gil Newburn Paul Condron Samantha J Holdsworth Tracy R Melzer Miriam Scadeng Eryn Kwon Daniel M Cornfeld Graeme M. Bydder

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Key Points

The aim is to explore how dSIR MRI can indicate brain changes associated with mild traumatic brain injury.
Analysis of MRI scans focusing on dSIR artifacts
Identification of symptom-associated white matter changes
Comparison with standard T2-FLAIR imaging
dSIR MRI revealed symptom-associated white matter changes not detected by standard T2-FLAIR
Indications suggest dSIR could serve as a useful imaging marker
Further studies needed to assess dSIR's sensitivity and specificity in clinical settings

Implication

Case series reports white matter changes seen on dSIR MRI in mild traumatic brain injury, suggesting new imaging markers.

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Cite This Study

McGeown et al. (2026) studied this question.

synapsesocial.com/papers/69aa710d531e4c4a9ff5b65a https://doi.org/10.1080/02699052.2026.2637171

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Enhancing T1 signal of normal‐appearing white matter with divided subtracted inversion recovery: A pilot study in mild traumatic brain injury2024 · 3 citations
2The role of incidental magnetization transfer in divided subtracted inversion recovery2025
3Assessment of multiple sclerosis using divided subtracted inversion recovery (dSIR) technique: a quantitative study2025
4The Role of Incidental Magnetization Transfer in Divided Subtracted Inversion Recovery2025
5Comparative evaluation of lesion conspicuity in white matter disease using double inversion recovery and T2 fluid-attenuated inversion recovery magnetic resonance imaging sequences: A cross-sectional observational studyObservational Study · 2026

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