In vivo clinical study examines magnetization transfer effects on dSIR signals in mTBI patients, suggesting new detection methods.
Motivation: The dSIR sequence shows changes in mTBI patients that have not been seen previously that correspond to a small difference in T1. The motivation of the study is to understand the origin of the signal changes. Goal(s): The goal is to examine the effect of incidental magnetization on the dSIR signal in normal subjects and patients with mTBI. Approach: This is an in vivo clinical study using sequence parameters to vary the incidental magnetization transfer. Results: Results showed that normal white matter exhibited a strong dSIR signal (T1) reduction in response to MT irradiation whereas a patient with mTBI did not. Impact: This study identifies a plausible mechanism for dSIR signal changes in white matter that may lead to more efficient methods of detecting mTBI and hypoxic injuries.
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Bydder et al. (2025) studied this question.
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