Keywords; Neuroinflammation, data acquisition and post processing, contrast mechanisms, white matter, drugs. MR contrast can be enhanced by exploiting the concept of tissue property filters (TPFs) by designing Multiplied, Added, Subtracted, and/or Divided Inversion Recovery (MASDIR) sequences to amplify contrast produced by small changes in white matter T1. The Divided, Subtracted IR (dSIR) sequence provides very high contrast depiction of subtle white matter changes due to disease that are not identified with standard T2-FLAIR imaging. This was demonstrated in patients with a history of methamphetamine addiction. MASDIR sequences could revolutionize the way that neuroinflammation is imaged in clinical practice.
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Condron et al. (2024) studied this question.
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