Prospective cohort study assesses non-breast and non-ovarian cancer risks in BRCA1 and BRCA2 carriers, indicating limited risks for most cancers.
Apart from pancreatic, prostate, and possibly stomach cancers for BRCA2 PV carriers, and possibly pancreatic cancer for BRCA1 PV carriers, there is no evidence that BRCA1 and BRCA2 PV carriers have substantially increased risks of other non-breast, non-ovarian cancers. Our prospective risk estimates are informative for cancer risk assessment for people with BRCA1 and BRCA2 PVs.
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Yang et al. (2026) studied this question.
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