Observational study shows increased pancreatic cancer risk in men and women with BRCA1 or BRCA2 variants, indicating a need for monitoring.
BRCA1/2 carriers had three times more cases of PC than expected, suggestively higher among female BRCA2 and male BRCA1 carriers. Cumulative risk of PC at 70 years in the latter two groups was less than 3% (0.5% and 0.7% in all Norwegian males and females observed until age 70 based on population data).
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Grindedal et al. (2025) studied this question.
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