Surgery alone achieves comparable survival to adjuvant therapy in T4aN0M0 gingival squamous cell carcinoma with clear surgical margins: A registry-based propensity-matched analysis

Key Points

• To evaluate whether adjuvant therapy provides a survival benefit for patients with T4aN0M0 gingival squamous cell carcinoma after surgery.
• Registry-based analysis of patients with T4aN0M0 GSCC
• Comparison of outcomes between surgery alone and adjuvant therapy
• Propensity matching to reduce bias in comparisons
• Surgery alone achieved comparable survival rates to adjuvant therapy
• Adjuvant radiation therapy or chemotherapy did not improve outcomes
• Findings suggest reconsideration of routine adjuvant therapy in this patient population

Abstract