What question did this study set out to answer?

This research examines how different body measurements relate to death from primary liver cancer (PLC) in men and women.

March 7, 2026JHEP ReportsOpen Access

Large cohort studies assessing sex associations between anthropometric indices and liver cancer death

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Authors

DYDan-Ni Yang HLHong-Lan Li QSQiu-Ming Shen

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Overview

Large cohort studies reveal distinct sex-specific patterns of adiposity linked to liver cancer mortality, indicating the need for targeted strategies.

Key Points

This research examines how different body measurements relate to death from primary liver cancer (PLC) in men and women.
Conducted two prospective cohort studies in China with 72,691 women and 59,892 men.
Examined 16 anthropometric indices (6 traditional, 10 emerging) and their association with PLC death.
Applied Cox proportional hazards regression models with restricted cubic spline functions for analysis.
300 women and 485 men died from PLC over a median follow-up of 22.0 years for women and 16.1 years for men.
Women showed positive linear associations for 11 indices with PLC death, especially in premenopausal women.
Men displayed U-shaped associations for 10 indices, indicating lower death risk at moderate adiposity levels.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69abc0b85af8044f7a4e973c https://doi.org/10.1016/j.jhepr.2026.101812

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March 7, 2026JHEP ReportsOpen Access

Large cohort studies assessing sex associations between anthropometric indices and liver cancer death

View Full Paper

Ask AI

Bookmark

Authors

DYDan-Ni Yang HLHong-Lan Li QSQiu-Ming Shen

Discussion

Member takes

Overview

Large cohort studies reveal distinct sex-specific patterns of adiposity linked to liver cancer mortality, indicating the need for targeted strategies.

Key Points

This research examines how different body measurements relate to death from primary liver cancer (PLC) in men and women.
Conducted two prospective cohort studies in China with 72,691 women and 59,892 men.
Examined 16 anthropometric indices (6 traditional, 10 emerging) and their association with PLC death.
Applied Cox proportional hazards regression models with restricted cubic spline functions for analysis.
300 women and 485 men died from PLC over a median follow-up of 22.0 years for women and 16.1 years for men.
Women showed positive linear associations for 11 indices with PLC death, especially in premenopausal women.
Men displayed U-shaped associations for 10 indices, indicating lower death risk at moderate adiposity levels.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69abc0b85af8044f7a4e973c https://doi.org/10.1016/j.jhepr.2026.101812

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