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March 7, 2026SHILAP Revista de lepidopterologíaOpen Access

Editorial: Unraveling molecular mechanisms of neurodegenerative disease development: insights from stem cell-derived 2D and 3D in vitro models

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Authors

SSStefania ScaliseMBMatteo BecattiVLValeria Lucchino

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Overview

Editorial reviews various molecular strategies and models impacting neurodegeneration and therapeutic discovery.

Key Points

  • The paper aims to explore insights into neurodegenerative disease mechanisms using novel experimental models and interventions.
  • Reviewed studies on copper metabolism and neurodegeneration effects of α-lipoic acid and phytochemical inhibitors.
  • Analyzed three-dimensional bioprinting technologies for modeling the blood-brain barrier.
  • Investigated neuroprotective effects of silymarin using nanoliposomes.
  • Evaluated non-invasive transcriptomic methods for studying neurological responses in autism spectrum disorder.
  • α-Lipoic acid effectively normalizes copper levels without toxicity in Alzheimer's disease models.
  • Identified potential inhibitors of cathepsin B through computational methods.
  • Silymarin-loaded nanoliposomes reduced toxicity and preserved cerebellar neuron integrity.
  • Peripheral omics approaches reveal significant changes in brain-related gene expression and microbial interactions.

Cite This Study

Scalise et al. (2026) studied this question.

synapsesocial.com/papers/69abc0de5af8044f7a4e97b0https://doi.org/10.3389/fmolb.2026.1802206
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