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March 7, 2026Open Access

Small Hepatoid Variant of Solid Pseudopapillary Neoplasm of the Pancreas: A Unique Case With Long-term Follow-up.

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Authors

HMHisakazu MatsumotoKMKosuke MINAGASUShotaro Ueno

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Overview

Case report demonstrates stability of hepatoid variant of solid pseudopapillary neoplasm, suggesting potential for nonoperative management.

Key Points

  • This report aims to characterize the long-term behavior of a rare hepatoid variant of solid pseudopapillary neoplasm.
  • Case report of a 37-year-old male with a 6 mm solid pancreatic lesion.
  • Diagnosis confirmed using endoscopic ultrasonography and immunohistochemical staining.
  • Patient declined surgical resection and opted for active surveillance.
  • Follow-up conducted over 5 years to assess tumor behavior.
  • The lesion remained morphologically stable without any clinical progression over 5 years.
  • Active surveillance appeared feasible for this small, asymptomatic tumor variant.
  • The case is the first to document long-term management of pancreatic hepatoid SPN nonoperatively.

Cite This Study

Matsumoto et al. (2026) studied this question.

synapsesocial.com/papers/69abc0de5af8044f7a4e97e1https://doi.org/10.1002/deo2.70310
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