Solid Pseudopapillary Neoplasms (SPNs) of the Pancreas: Appraisal of Contemporary Clinicopathologic Features ‐ Clinical Implications and Surgical Outcomes of Patients Treated and Followed at a Single Institution

Subhadra Acharya; Luke T. Meredith; Z. Kaplan; Rehana Persaud; David Moskal; Brandon Wummer; Wei Jiang; Richard Zheng; Haresh Naringrekar; Harish Lavu; Charles J. Yeo; Avinoam Nevler; Wilbur B. Bowne

doi:10.1002/jso.70248

April 16, 2026Journal of Surgical Oncology

Solid Pseudopapillary Neoplasms (SPNs) of the Pancreas: Appraisal of Contemporary Clinicopathologic Features ‐ Clinical Implications and Surgical Outcomes of Patients Treated and Followed at a Single Institution

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Key Points

The aim is to evaluate the clinicopathologic features and surgical outcomes of patients with solid pseudopapillary neoplasms.
Analysis of patient records at a single institution
Assessment of tumor characteristics and recurrence rates
Follow-up of surgical outcomes
Patients had a favorable oncologic outcome overall
Recurrences were more common in older patients with larger tumors
Pathogenic co-mutations were identified in tumors of some patients
One case involved traumatic tumor rupture

Implication

Reports favorable oncologic outcomes in patients with solid pseudopapillary neoplasms, indicating potential for effective management.

Abstract

Patients with solid pseudopapillary neoplasms had a favorable oncologic outcome. Recurrence/metachronous metastasis occurred in older patients with larger tumors, each containing a pathogenic co-mutation, and one patient experiencing traumatic tumor rupture.

Discussion

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Cite This Study

Acharya et al. (2026) studied this question.

synapsesocial.com/papers/69e47282010ef96374d8e8e1 https://doi.org/10.1002/jso.70248

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Solid Pseudopapillary Neoplasms (SPNs) of the Pancreas: Appraisal of Contemporary Clinicopathologic Features ‐ Clinical Implications and Surgical Outcomes of Patients Treated and Followed at a Single Institution

Key Points

Implication

Abstract

Discussion

Cite This Study

Solid Pseudopapillary Neoplasms (SPNs) of the Pancreas: Appraisal of Contemporary Clinicopathologic Features ‐ Clinical Implications and Surgical Outcomes of Patients Treated and Followed at a Single Institution

Key Points

Implication

Abstract

Discussion

Cite This Study

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