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March 7, 2026BiochemistryOpen Access

The Power of Protein Dynamics in Binding and Allostery

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Authors

ALA. Christopher LeePSPaul J. Sapienza

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Overview

This review examines how protein dynamics influence binding cooperativity in protein interactions, suggesting new insights into allosteric regulation.

Key Points

  • This review aims to clarify the role of protein dynamics in allosteric regulation and binding events.
  • Reviewed experimental studies on protein dynamics and allostery
  • Analyzed NMR relaxation measurements of order parameters
  • Highlighted distinct dynamic strategies in various proteins
  • Dynamic allostery involves localized dynamics enhancing binding cooperativity
  • Changes in picosecond-nanosecond timescale dynamics exert significant entropic forces
  • Disordered tails in proteins play a surprising role in dynamic allostery

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69abc0de5af8044f7a4e9900https://doi.org/10.1021/acs.biochem.5c00782
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