Oligodendrocyte-specific Fus depletion preserves CA1 single-unit fidelity and stabilizes network dynamics during chronic recording

Key Points

• The study aims to investigate how fus depletion in oligodendrocytes affects single-unit fidelity and network dynamics during chronic recordings in the hippocampus.
• Examined the effects of fus depletion on oligodendrocytes in the hippocampus.
• Conducted chronic recordings to assess single-unit fidelity and network dynamics.
• Analyzed the impact on cortical communication and population-level dynamics.
• Fus depletion improved single-unit fidelity in CA1 hippocampal neurons.
• Disrupted communication across cortical networks.
• Highlighted distinct roles of oligodendrocytes in individual versus collective neural activity.