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March 7, 2026Frontiers in NeuroscienceOpen Access

Effects of GPR110 expression on neurobehavioral outcomes in mice

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Authors

MMMariam MelkumyanBHBill X. HuangJTJoel Toro

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Overview

Investigates how changing GPR110 levels affects behavior in adult mice, suggesting new approaches for mental health disorders.

Key Points

  • To examine the impact of GPR110 expression on behavior and molecular pathways in adult mice.
  • Used mice with GPR110 deletion and overexpression in glutamatergic neurons
  • Conducted behavioral testing in open field and learning tasks
  • Performed transcriptomic and proteomic analyses of brain tissues
  • Deletion of GPR110 increased immobility in behavioral tests and impaired learning
  • Downregulation of genes involved in synaptogenesis and neurotransmission observed
  • Overexpression of GPR110 reduced anxiety and compulsive behaviors, enhancing receptor signaling and synaptic communication

Cite This Study

Melkumyan et al. (2026) studied this question.

synapsesocial.com/papers/69abc0de5af8044f7a4e992bhttps://doi.org/10.3389/fnins.2026.1774433
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