Observational data show improved pain and function in knee osteoarthritis after polyacrylamide hydrogel injection, suggesting a promising treatment option.
A single IA injection of iPAAG was associated with sustained improvements in pain and function, with a favourable safety profile maintained through 5 years. These observational data support iPAAG as a promising long-acting, non-surgical treatment option for knee OA.
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Bliddal et al. (2025) studied this question.
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