What question did this study set out to answer?

The research aims to determine the influence of clonal hematopoiesis of indeterminate potential (CHIP) on treatment response and the tumor microenvironment in breast cancer patients undergoing neoadjuvant chemotherapy.

March 7, 2026Journal of Mammary Gland Biology and NeoplasiaOpen Access

Impact of Clonal Hematopoiesis of Indeterminate Potential on Treatment Response and Tumor Microenvironment in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

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The research aims to determine the influence of clonal hematopoiesis of indeterminate potential (CHIP) on treatment response and the tumor microenvironment in breast cancer patients undergoing neoadjuvant chemotherapy.
Analyzed tumor sequencing data from The Cancer Genome Atlas (TCGA) for mutations in CHIP-driver genes.
Conducted a retrospective review of 44 breast cancer patients treated with neoadjuvant chemotherapy.
Evaluated associations between CHIP mutations and clinical outcomes such as overall survival and disease-free survival.
Patients with CHIP mutations showed significantly worse overall and disease-free survival.
CHIP positivity correlated with extensive residual disease post-treatment, indicating chemotherapy resistance (P = 0.027).
Transcriptomic analysis revealed diminished CD8 + T cell infiltration and dysregulated immune pathways in CHIP-positive tumors.

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Implication

Observational study investigates clonal hematopoiesis effects on chemotherapy outcomes in breast cancer, suggesting its role as a biomarker.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69abc1015af8044f7a4e9aff https://doi.org/10.1007/s10911-026-09603-0

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Implication

Observational study investigates clonal hematopoiesis effects on chemotherapy outcomes in breast cancer, suggesting its role as a biomarker.

Impact of Clonal Hematopoiesis of Indeterminate Potential on Treatment Response and Tumor Microenvironment in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

Key Points

Discussion

Implication

Cite This Study

Impact of Clonal Hematopoiesis of Indeterminate Potential on Treatment Response and Tumor Microenvironment in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

Key Points

Discussion

Implication

Cite This Study

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