What question did this study set out to answer?

The aim is to evaluate the efficacy of pomegranate peel extract nanoparticles in treating psoriasis in a rat model.

March 7, 2026Scientific ReportsOpen Access

Nanoformulation of pomegranate peel extract enhances anti-psoriatic efficacy in a rat model

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Preclinical study demonstrates pomegranate peel nanoparticles reduce psoriasis severity in rats, suggesting a new treatment option.

The aim is to evaluate the efficacy of pomegranate peel extract nanoparticles in treating psoriasis in a rat model.
Developed nanoparticles from pomegranate peel extract via acid hydrolysis.
Characterized nanoparticles for size, stability, and bioactivity.
Conducted in vitro assays for cytotoxicity, antioxidant, and anti-inflammatory effects.
Tested in vivo efficacy using psoriatic rats divided into control groups, with various treatments.
PGNPs showed superior stability and lower cytotoxicity compared to the crude extract.
In vitro PGNPs exhibited higher antioxidant and anti-inflammatory activities than PGE.
In vivo, PGNPs significantly reduced psoriatic lesions and normalized oxidative stress markers.
Histopathological examination revealed improved skin regeneration with PGNPs.

ZID et al. (2026) studied this question.

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