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March 7, 2026BMJ OpenOpen Access

Association of diabetes severity with cognitive function in US adults: a cross-sectional analysis of the AI-READI multicentre cohort

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Authors

KUKenneth Minyong UmBKBenjamin J KimGYGui-Shuang Ying

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Overview

Cross-sectional analysis reveals diabetes severity impacts cognitive function in US adults, indicating the need for routine screening.

Key Points

  • To investigate the relationship between type 2 diabetes severity and cognitive function among US adults.
  • Conducted a cross-sectional analysis using data from the AI-READI cohort.
  • Participants classified into four glycaemic groups: controls, pre-diabetes, medication-controlled T2DM, and insulin-dependent T2DM.
  • Cognitive function assessed using the Montreal Cognitive Assessment (MoCA) total and domain scores.
  • Prevalence of cognitive impairment defined as MoCA scores below 26.
  • Significant differences in MoCA total scores observed across glycaemic groups (p<0.001).
  • Lowest mean MoCA score (24.0) in insulin-dependent T2DM group, highest (25.8) in controls.
  • Cognitive impairment prevalence increased from 39% in controls to 58% in the insulin-dependent group.
  • Increased diabetes severity correlated with higher risk of cognitive impairment (adjusted OR 1.85 for insulin-dependent T2DM).

Cite This Study

Um et al. (2026) studied this question.

synapsesocial.com/papers/69abc1535af8044f7a4e9ddahttps://doi.org/10.1136/bmjopen-2025-110831
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cognitive decline and diabetes in the clinical setting2024
  2. 2A study to assess the relationship between cognitive impairment and glycemic management in patients with type 2 diabetes using MoCA score2025
  3. 3A COMPARATIVE STUDY ON COGNITIVE IMPAIRMENT AMONG ADULTS WITH TYPE 2 DIABETES MELLITUS2024 · 1 citations
  4. 4Implications of cognitive and daily living capabilities on early type 2 diabetes management: a preliminary case–control study2024 · 2 citations
  5. 5Unravelling the Association of Cognitive Impairment among Type 2 Diabetes Mellitus Patients: A Cross-sectional Study2026