In a fate mapping study, transcriptional adaptation of NK cells during gestation reveals implications for pregnancy success.
These findings identify a novel transcriptional program that shapes NK cell plasticity in response to T-bet downregulation across gestation. Rather than undergoing lineage diversion, dNK cells adapt to the decidual environment via transcriptional compensation and subset redistribution during pregnancy. This work sheds light on the temporal coordination of innate immune function relevant to pregnancy success.
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Mohamed et al. (2026) studied this question.
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