Photoinduced Dearomative Oxyimination of Indoles Using Oxime Esters as Bifunctional Radical Precursors

A photoinduced, metal-free, and regioselective oxyimination of indole derivatives has been developed, enabling efficient difunctionalization via simultaneous C-O and C-N bond formation. Using oxime esters as dual radical precursors, this mild and sustainable strategy achieves a high atom economy and excellent diastereoselectivity. It can be applied to benzofuran and benzothiophene derivatives. This method provides a versatile and practical approach for dearomative transformations, offering new opportunities for the diastereoselective functionalization of indole derivatives.