What question did this study set out to answer?

The aim is to evaluate intralesional uptake patterns of FDG and PSMA in various neoplastic lesions using qualitative and semiquantitative assessments.

March 7, 2026Hematology Transfusion and Cell TherapyOpen Access

Qualitative and Semiquantitative Assessment of Intralesional Uptake Mismatch Between FDG and Psma Pet/Ct in Neoplastic Lesions

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Authors

APAdrhyann Jullyanne de Sousa PortilhoUniversidade Estadual de Campinas (UNICAMP)MTMaria Emilia Seren TakahashiUniversidade Estadual de Campinas (UNICAMP)SKSimone KubaUniversidade Estadual de Campinas (UNICAMP)

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Implication

Retrospective cross-sectional study assesses metabolic patterns in malignancies, suggesting distinct tumor biology.

Key Points

The aim is to evaluate intralesional uptake patterns of FDG and PSMA in various neoplastic lesions using qualitative and semiquantitative assessments.
Conducted a retrospective cross-sectional analysis of PET/CT images from patients with several types of cancer.
Patients underwent both FDG and PSMA-targeted PET/CT scans within a defined interval.
Qualitatively assessed intralesional uptake differences categorized into peripheral, central, diffuse, or segmental types.
Measured semiquantitative parameters like SUVmax, SUVmean, MTV, and TLM using ImageJ software.
Identified predominantly peripheral PSMA uptake in 46% of lesions, especially notable in thyroid cancer cases.
Segmental, central, and diffuse uptake patterns were also observed in different proportions across lesions.
No significant differences in semiquantitative parameters between FDG and PSMA at the population level were found, likely due to limited sample size.

Cite This Study

Portilho et al. (2026) studied this question.

synapsesocial.com/papers/69abc1765af8044f7a4ea231 https://doi.org/10.1016/j.htct.2026.106332

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Qualitative and Semiquantitative Assessment of Intralesional Uptake Mismatch Between FDG and Psma Pet/Ct in Neoplastic Lesions

Discussion

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Implication

Key Points

Cite This Study

Qualitative and Semiquantitative Assessment of Intralesional Uptake Mismatch Between FDG and Psma Pet/Ct in Neoplastic Lesions

Discussion

Member takes

Implication

Key Points

Cite This Study

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