Observational analysis reveals the context-dependent value of biopsy-based transcriptomics in kidney transplantation, suggesting the need for targeted frameworks.
Biopsy-based transcriptomics provides biologically meaningful information but has not yet demonstrated outcome-improving clinical utility. Its value is highly context- dependent and currently best defined for selected scenarios rather than routine use. Prospective interventional studies and consensus-based interpretative frameworks are required to determine how molecular information should inform clinical decision-making in kidney transplantation.
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Wellekens et al. (2026) studied this question.
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