What question did this study set out to answer?

This research aims to evaluate the dose-response relationship of streptozotocin in female NSG mice compared to males to identify optimal dosing for diabetes induction.

March 7, 2026Scientific ReportsOpen Access

Comparative analysis of dose-response variability and severity in STZ-induced diabetes: female vs. male NSG mice

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Authors

STSteven R. TalbotMedizinische Hochschule Hannover MHMiriam HeiderMedizinische Hochschule Hannover MWMartin WirthMedizinische Hochschule Hannover

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Implication

Comparative analysis reveals sex-specific responses to streptozotocin in diabetes induction, suggesting implications for preclinical research design.

Key Points

This research aims to evaluate the dose-response relationship of streptozotocin in female NSG mice compared to males to identify optimal dosing for diabetes induction.
Evaluated single doses of streptozotocin ranging from 125 to 225 mg/kg body weight.
Assessed hyperglycemia induction and animal health following each dosage.
Compared outcomes between male and female NSG mice regarding diabetes induction and weight loss.
Doses of 125 and 150 mg/kg failed to induce diabetes, while 200 and 225 mg/kg caused severe hyperglycemia and weight loss.
175 mg/kg induced stable hyperglycemia in about 90% of subjects with acceptable weight loss.
Females required approximately 25 mg more streptozotocin for similar outcomes compared to males.

Cite This Study

Talbot et al. (2026) studied this question.

synapsesocial.com/papers/69abc1b45af8044f7a4eaa32 https://doi.org/10.1038/s41598-026-42408-z

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Implication

Comparative analysis reveals sex-specific responses to streptozotocin in diabetes induction, suggesting implications for preclinical research design.

Comparative analysis of dose-response variability and severity in STZ-induced diabetes: female vs. male NSG mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparative analysis of dose-response variability and severity in STZ-induced diabetes: female vs. male NSG mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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