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The aim is to analyze KRAS variants to understand their functional impacts on oncogenic activity.

Abstract PR006: Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

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The aim is to analyze KRAS variants to understand their functional impacts on oncogenic activity.
Conducted deep mutational scanning screens on wild-type and KRASG12D mutant alleles
Characterized oncogenic potential of KRAS variants
Developed a model linking KRAS mutations frequency and their transforming capabilities
Performed biochemical and structural analyses on suppressor variants
Identified several novel transforming alleles associated with KRAS variants
Discovered that protein instability and conformational rigidity can reduce oncogenic KRAS activity
Mapped single amino acid substitutions that regulate KRAS function

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Comprehensive analysis identifies mechanisms impacting KRAS activity in cancer, suggesting therapeutic avenues.

Kwon et al. (2026) studied this question.

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